General Spoilers

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General Spoilers:

• 09/19 - "I want to be clear that Derek loves Meredith," [Shonda Rhimes] said as if to put the debate to rest once and for all. "Derek loves Meredith more than anything and I can't imagine Derek going anyplace else other than Meredith." [...] "A lot of people aren't sold on Izzie and George," she acknowledged. "I think the mistake that everyone makes is that we are telling you Izzie and George are the love story of the century; they're not the love story of the century. And when other people find out about Izzie and George - remember, people don't know about them yet - other people might think that's not a good idea either." [...] I caught up with James Pickens Jr. on the red carpet and he teased that there will be some drama surrounding the Chief's living situation (i.e., you won't believe who's moving in next door). Source: Ask Ausiello @ TV Guide
• 08/17 - A new season of Grey's Anatomy and some fresh new spoilers! Many of these will be in the season premiere September 27th, but some will obviously carry over for a few episodes, and some are rather obvious from how we saw the plot going in the season finale. George decides to repeat his internship, meaning he'll be with all the new interns including Lexie, Meredith's half sister. No word on which new resident will have either George or Lexie, but we know it won't be Izzie. The rest of the former interns are now residents, and are having issues with having to report to Callie. Meredith joins Cristina on her honeymoon before they both return to Seattle Grace two weeks after Burke walked out on Cristina. And yes, Burke has resigned. And Meredith uses the time away to consider her own relationship with Derek. Bailey is still pretty upset with Richard for choosing Callie for Chief Resident and is struggling to find her place on the hierarchy of the hospital. Richard takes Derek's advice and decides to return to his position as Seattle Grace's Chief. And he and Adele get back together. After Addison leaves, Mark tries to befriend Derek again. and it sounds as though his relationship with Meredith will also play a role in this. One of the interns from last season's season finale has also snagged a spot as a recurring character on Grey's Anatomy. Candice Afia will be returning to Grey's Anatomy. Joseph Williamson (who played the hot intern in the season finale) will be returning as well. Of the remaining two interns we saw last season, neither are returning as this season's interns. Source: SpoilerBuzz
• 08/15 - As per Ausiello's Vodcast on TV Guide.com, Callie will learn the truth about Gizzie during one of the following: 1) The first scene of the premiere, 2) November Sweeps, 3) Episode Three entitled "Let The Truth Sting." Source: SpoilerTV
• 08/08 - I hear Lexie and Derek are not happening - at least not initially. Word around Seattle Grace is that Lexie is being paired with Alex. That should certainly make things interesting when Jane Doe/Ava/Rebecca reappears. Source: Ask Ausiello @ TV Guide
• 07/12 - Entering their first year as residents, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new interns are George, forced to repeat his internship after failing his exams, and Lexie Grey, Meredith's half-sister. Actress Chyler Leigh joins the cast as Lexie Grey. "Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel "Izzie" Stevens, T.R. Knight as George O'Malley, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan and Chyler Leigh as Lexie Grey. Source: ABC
• 07/11 - Grey's Anatomy has promoted Chyler Leigh (aka Mer's McDreaming half-sis Lexie) to a series regular, an ABC Studios rep confirms. Source: The Ausiello Report
• 07/02 - I'm hearing [that George and Callie's relationship] is proving quite a difficult puzzle for Shonda Rhimes, who is fully aware of the fan backlash over last season's George and Izzie hookup and has been doing quite a few rewrites. Source: Kristin on E!Online
• 06/12 - Executives tied to the show say the fourth-season plan is to add several cast members, including at least one fresh-faced new intern: Meredith Grey's half-sister Lexi (Chyler Leigh) will become a frequent presence with a multi-episode story arc. They are also seeking a new recurring male character to compete with Patrick Dempsey's Dr. McDreamy. Source: AOL
• 06/08 - Multiple sources are telling me that Isaiah Washington will not be returning to Grey's Anatomy next season. An ABC Studios spokesperson confirms that the actor's contract option has not been picked up, but declined further comment. [...] Washington's rep, Howard Bragman, confirmed the news, adding that his client was informed by Grey's executive producer Shonda Rhimes earlier today that he was not being invited back to the show. [...] Plot-wise, it won't be difficult to explain Washington's absence. In last month's season finale, Burke left Cristina at the altar and moved out of their apartment. Source: The Ausiello Report
• 05/09 - Sources close to Grey’s Anatomy tell me that Chyler Leigh has been offered a multiple-episode arc for next season. Source: Kristin on E!Online [Note: Ausiello says that Chyler Leigh was offered a 13-episode arc.]
• 02/10 - I know that casting agents have been in Toronto recently, looking to cast a girl between the ages of 10 and 12 for an arc next season. Now, as much as a great show like Grey's might plan ahead, this seems to be way ahead, if you ask me. So, my first thought is that this girl is Izzie's bio-daughter. Source: Kristin on E!Online [Note: We have seen Izzie's daughter this season. Does this spoiler mean that she'll be back next season? Or is the 10-to-12-year-old girl not Izzie's daughter?]